Can I Give My Cat Benadryl?

Yes, with care
Diphenhydramine is commonly referenced for cats at published doses. The published veterinary reference range for diphenhydramine in cats is 1-2 mg per kg of body weight, given every 8-12h. In practice: 2-4 mg total per cat. Bitter; cats foam/drool at the taste. Paradoxical excitement possible.
Source: Merck Veterinary Manual
Get the exact range for your cat's weight

Skip it or ask a vet first if

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Published range by weight

WeightDiphenhydramine (published range)
8 lb cat3.6-7.3 mg
10 lb cat4.5-9.1 mg
14 lb cat6.3-13 mg

Computed from the published 1-2 mg/kg reference range, every 8-12h. Product strengths rarely split evenly, so round DOWN to the nearest practical dose and confirm with your vet.

Dogs use a different amount

The published dog reference (1 mg per lb (2.2 mg/kg)) differs from the cat range. Never split the difference between species; check the dog page instead.

About Diphenhydramine

Diphenhydramine is an antihistamine, a class used to blunt allergic responses like itching, hives, and insect-sting swelling. You will see it sold as Benadryl, and the label strength on the box is what matters for the math, not the brand. Reference data on this page reflects published veterinary sources, not a prescription for your cat.

What to have ready when you call the vet

Whether you are confirming a dose or reporting that your cat already got into something, the call goes faster with four facts ready: your cat's current weight, the exact product name and strength from the label, how much was given or eaten, and roughly when. With those, most clinics can answer in one call.

The safe habit

Confirm any medication decision with your veterinarian, who knows your cat's health history and other medications. VetDose shows published reference data, not prescriptions.

See also

Other antihistamine questions for cats